These Baked Shrimp Po’ Boy Sandwiches with Spicy Mayo are a healthy twist on a classic Louisianan sandwich. They are easy to make and take just 30 minutes.
So I have to admit, I had never even heard of a Po’ Boy sandwich until I watched the Food Network. I had actually never seen a Po’ Boy sandwich until I read Now Eat This, a cookbook by Rocco DiSpirito. And I’d never eaten a Po’ Boy sandwich until I made this one. Gasp! I know; I was totally missing out!
What the heck? I am even more shocked because I am married to a man that grew up in Louisiana. How could he not share this sandwich with me? Well, regardless, this sandwich is everything I imagined it would be and more. In fact, it’s freaking amazing!!! Unbelievable and a new favorite! Move over turkey, bacon, and avocado, there’s a new “boy” in town.
This recipe doesn’t completely follow its fried original because the shrimp is baked. I enjoy that even more because it saves over 400 calories preparing it this way! The spicy mayo completes this sandwich and leaves you with a tiny kick. I am so happy that I found my Po’ Boy and will be sharing this with everyone I know here in CO.
I mean, come on, we cowboys need a little more southern hospitality.
Enjoy! XOXO San
How do you make Baked Shrimp Po’ Boy Sandwiches with Spicy Mayo?
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Preheat oven to high broil. Place red pepper on baking sheet and coat with olive oil and season with salt and pepper to taste. Broil the pepper for 2-3 minutes and then turn and the pepper and broil for another 2-3 minutes until pepper is tender. Remove from oven and let it cool, then slice thinly.
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Heat oven to 450 degrees. Place a wire rack on a baking sheet and set aside for later.
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Spread the flour in a shallow dish, I use a dinner plate. Place the panko in a separate shallow dish or dinner plate.
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In a small bowl, whip the egg whites with a whisk until they are extremely foamy but not yet holding peaks.
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Working in batches, put the shrimp in the flour, cover completely and shake off any extra. Then add dip the shrimp in the egg whites; toss to coat completely. Then add the shrimp to the panko and turn to completely coat.
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Place the shrimp on the wire rack, and season generously with salt. Repeat process with remaining shrimp.
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Bake on rack until breading is golden and crispy and shrimp are cooked through, about 8 minutes.
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Stir together mayo and Sriracha. Prepare buns by separating the top and bottom buns. I love using my homemade Whole Wheat Rolls. Spread the mayo on each side of the bun.
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Then top each bun with lettuce and peppers. Pile the amount of shrimp you like on one half of the bun, do this on top of the peppers and lettuce. Then top with the other half of the bun. Serve and enjoy!
Looking for more sandwich recipes? Check these out: Cheesy Buffalo Chicken Sliders, French Onion Meatball Sandwiches, and Grilled Chicken Carbonara Sandwiches.
Don’t forget to pin this to your favorite Pinterest board to save for later!
Baked Shrimp Po’ Boy Sandwiches with Spicy Mayo

Ingredients
- 1/2 cup whole wheat flour
- 2 cups panko breadcrumbs
- 3 egg whites
- 8 ounces large shrimp peeled and de-veined
- salt
- 1/2 low-fat mayo I use olive-oil mayo
- 2 tablespoon Sriracha sauce
- 4 whole wheat buns cut in half
- 4 leaves romaine shredded
- 1/2 red bell pepper
- 1/2 teaspoon olive oil
Instructions
- Preheat oven to high broil. Place red pepper on baking sheet and coat with olive oil and season with salt and pepper to taste. Broil the pepper for 2-3 minutes and then turn and the pepper and broil for another 2-3 minutes until pepper is tender. Remove from oven and let it cool, then slice thinly.
- Heat oven to 450 degrees. Place a wire rack on a baking sheet and set aside for later.
- Spread the flour in a shallow dish, I use a dinner plate. Place the panko in a separate shallow dish or dinner plate.
- In a small bowl, whip the egg whites with a whisk until they are extremely foamy but not yet holding peaks.
- Working in batches, put the shrimp in the flour, cover completely and shake off any extra. Then add dip the shrimp in the egg whites; toss to coat completely. Then add the shrimp to the panko and turn to completely coat.
- Place the shrimp on the wire rack, and season generously with salt. Repeat process with remaining shrimp.
- Bake on rack until breading is golden and crispy and shrimp are cooked through, about 8 minutes.
- Stir together mayo and Sriracha. Prepare buns by separating the top and bottom buns. I love using my homemade Whole Wheat Rolls. Spread the mayo on each side of the bun.
- Then top each bun with lettuce and peppers. Pile the amount of shrimp you like on one half of the bun, do this on top of the peppers and lettuce. Then top with the other half of the bun. Serve and enjoy!

Kids Review: My husband and I loved this, as well as all of our friends we made it for. The kids were loving the shrimp but the spicy mayo made them shutter and this was without them even trying it.
Adapted from Rocco DiSpirito
I haven’t ever HAD a po boy sandwich. I guess it’s not common here in ct? I need to travel more!
Humm….I love Poor Boy Sandwiches. I have never thought of baking! I will have to give this a try. Looks delicious!
Look how fat that sandwich is – how did you even fit that into your mouth LOL? It sounds great and looks amazing!
LOL! That is funny! It was easy, I devoured it but did have some spicy mayo on my face…xo San
What an interesting twist on an old fav! Never would have thought of putting shrimp in a Po Boy Sandwich. Thanks for sharing!!
oh wow that looks good! the photos are amazing too!
I’ve never heard of a Po’ Boy Sandwich either! It sounds good though.
That looks satisfying!
This looks wonderful! I live in south Texas near the Gulf where shrimp is king. I will be trying this for sure. Thanks!
Big Texas Hugs,
Susan and Bentley
Mmm those look so yummy! I haven’t had a po boy forever! Can’t wait to try this at home!
Okay, my only suggestion is try eating it on more of a sub roll. It holds all the goodness in together better. I definitely want to try making this recipe though! I even bough shrimp the other day. This will be a perfect way to cook them.
Brandi – totally agree on the sub roll but I am trying to eat healthier, notice the word trying so that is why I used the whole wheat bread – a homemade recipe. But YES this are so good on subs rolls!!! xo San
This looks very good! Just without the avocado..
That looks so good. Love that you baked them.
Oooh, summer is coming, which means that it will be the perfect time to make this with some fresh shrimp… yum!
I never had one of these before but I would love to try this!
I’ve never tried one of these sandwiches before, but it looks very filling! Where I live shrimp is so expensive that this is not poor boy, but “rich boy” sandwich! The panko must make this sandwich very tasty!
Now I am not one for shrimp but that looks really good. I’ll have to share it with my husband who does like shrimp. Maybe I could use a fish instead.
Just looking at this photo makes my mouth water. I have never had a Po’ Boy Sandwich — I’ve never been to Louisiana — but I would love to make this and find out what I’ve been missing.
Sounds like an interesting sandwich. I’m a die hard turkey, bacon, and avocado fan, also, so if you’re sold, it must be good!
Wow!! That Looks Delicious!!
I am a shrimp fanatic, and this looks delicious! I love when you make healthy versions of some of my favorites!
This looks tasty! I hadn’t had a po’ boy until I visited New Orleans. I hadn’t known what I was missing out on.
I like that the shrimp is baked! That’s definitely a plus to me. I also like spicy mayo mmmmmm.
Look So Yummy!!
Oh my god, that looks so delicious. Thanks so much for the recipe.
I am not a fan of shrimp, but I bet my husband would like this.
This looks delicious! I have never had a Po Boy either, so I may have to join the club and make this one 😉
wow that looks great, well balanced and delicious!
I adore shrimp most any way you cook them.
Oh man I love po boy sandwiches. I couldn’t get enough of them when I was in Nola last year!
My sister is a huge fan of shrimp and she would LOVE this recipe!
I love Po’ Boy sandwiches A LOT. Yours looks delicious. I am salivating over here!
Sandra,
I think it’s going to be my favorite too! Trying it first chance I get. Pinned!
Hugs,
Wanda Ann @ Memories by the Mile
It looks delicious and I love the calorie saving plus the health factor. I’ll definitely give it a try.
That looks delicious! I am not a big fried sandwich person, but I can sink my teeth into that 🙂
I already replied, but I saw this again today and laughed at the shuttering of your friends. It makes me laugh. They might be surprised if they tried it. 🙂
We have a little restaurant in town that makes Po’ Boy sandwiches, but I have to admit, this one looks much nicer 😉
My kids wouldn’t be into this, but I think it sounds great. You have to go to New Orleans, po’boy sandwiches are everywhere!
I’m not a huge seafood person, but this looks good and I’m sure my husband would like it.
I have never eaten a schrim sandwitch but this looks too good to pass! Thank you for sharing!
That looks so delish!
Looks great! I’ve heard of these sandwiches but just don’t order (or make) them much.
That’s such a shame that your Louisiana-raised hubby never shared the po’boy with you, Sandra, but I’m so glad that you’ve had one and figured out how to make it at home! The po’boy is one of my guilty pleasures whenever we’re visiting family in Louisiana, and I love that you lightened up this traditionally fried sandwich by baking the shrimp. I’m gonna have to try this soon!
ALSO, this was one of my favorite things shared during last week’s That’s Fresh Friday. I’m sharing it on my blog tonight for the new link-up as one of my favorites. I hope you don’t mind!
Happy cooking to you!
I LOVE Po Boys and this one looks so amazing!! I love that the shrimp is baked! 🙂