One Pan Southwestern Pork Tenderloin is full of bold flavors. Simple, gorgeous, and delicious, this is the perfect meal to serve this holiday season.
My entire family loves this One Pan Southwestern Pork Tenderloin. While it is one of the best ways to serve it, we also love these recipes: Buffalo Pork Tenderloin Fries, or these crispy Pork Tenderloin Sandwiches.

I love one-pan or one-pot meals. The main reason is, of course, the easy clean-up. This recipe requires baking everything on just one pan, including the veggies, seasonings, oil, and meat, which means a lot of flavors. It’s easy, and the ingredients are fresh and straightforward.
Whether it’s on a busy school night, having friends over, or trying to find a meal that is just perfect to serve during the holidays, this One Pan Southwestern Pork Tenderloin is the way to go.

While I loved the kick of the jalapeno (and so did my hubby), the kids didn’t so much. Cutting vegetables like this allowed everyone to pick what they wanted. Of course, my hubby and I ate those extra veggies the kids left behind.

We served the One-Pan Southwestern Pork Tenderloins with corn tortillas, cilantro, and cotija cheese. Also, you could serve the tenderloin with rice and beans on the side. I am thinking this is what I will do next time. This time around, I cut up the pork tenderloin and made tacos, but most of my kids just ate it straight from their plates.
My son, Cannon, loved the tenderloin. He would agree, “Not all pork is created equal”. I’m sure he would have eaten the entire package on his own if given the chance, meaning this will be added to our family’s meal rotation.

My dad took the leftovers and was going to make a hearty breakfast the following day, which sounded just as good. The tenderloin would pair well with some small potatoes on the baking pan, seasoned with the same Southwestern spices. Add an over-easy egg, and breakfast is served.
Want a fiesta but not a mess? Or are you looking for a simple yet gorgeous holiday meal? Try this one-pan southwestern pork tenderloin—it’s full of flavor and on your table in under 30 minutes.
How do you make One-Pan Southwestern Pork Tenderloin?
- Preheat oven to 425 degrees F.
- Prepare Southwestern seasoning in a small mixing bowl. Add all of the seasoning ingredients and stir until well combined. Set aside.
- Add the pork tenderloin and all of the vegetables to a large rimmed baking sheet. Drizzle with oil and sprinkle 3-4 tablespoons of the Southwestern seasoning over them. Toss to coat and rub to cover the pork tenderloin.
- Place into the oven and bake until thoroughly cooked, about 25-30 minutes.
- Once the pork tenderloin is fully cooked, turn the oven to high broil. Broiling the veggies and pork tenderloin will give them a nice caramelization.
- Serve immediately with corn or flour tortillas, garnished with cilantro and cheese.
Pin to Pinterest.
One Pan Southwestern Pork Tenderloin

Ingredients
Southwestern Rub
- 4 1/2 teaspoons salt
- 4 tablespoons brown sugar
- 2 teaspoons garlic powder
- 2 teaspoons onion powder
- 1 tablespoon smoked paprika
- 1 tablespoon black pepper
- 4 teaspoons cumin
- 1 tablespoon chili powder
- 1 tablespoon mexican oregano
Veggies and Pork
- 1 red pepper cut into 1-inch cubes
- 1 yellow pepper cut into 1-inch cubes
- 1 orange pepper cut into 1-inch cubes
- 1 purple onion cut into 1-inch cubes
- 3 jalapenos sliced
- 10 ounce grape tomatoes
- 1/4 cup olive oil
- 2 1/4 pounds Smithfield Prime Fresh Pork Tenderloin
- 3-4 tablespoons Southwestern Rub recipe above
Serving Suggestions
- cotija cheese
- cilantro
- sour cream
- corn tortillas
Instructions
- Preheat oven to 425 degrees F.
- Prepare Southwestern seasoning in a small mixing bowl. Add all of the seasoning ingredients and stir until well combined. Set aside.
- Add pork tenderloin and all of the vegetables to a large baking rimmed baking sheet. Drizzle with oil and sprinkle 3-4 tablespoons of the Southwestern seasoning over the pork tenderloin and vegetables. Toss to coat and rub to cover the pork tenderloin.
- Place into oven and bake until thoroughly cooked; about 25-30 minutes.
- Once the pork tenderloin is fully cooked turn the oven to high broil. Broil the veggies and pork tenderloin, this will give them a nice caramelization.
- Serve immediately with corn or flour tortillas, garnished with cilantro, sour cream, and cheese.





This looks delicious!! My hubby is not a fan of anything too hot, so I would use mild green chiles.
Pork tenderloin is one of my most favorite meats, no fat or bone just fork tender juicy meat!! They can be marinated and cooked whole or cut in chunks for kebabs or even a stew. Just please do not over cook!!
I wanted to pin this recipe but I couldn’t>
Barbara –
Here is the pin link: https://www.pinterest.com/pin/512425263836491658/
You can pin by just hoovering over any picture and a Pin It will come up. Enjoy!
Love this recipe, simple to prepare and very tasty
Thank you!